c) Roanoke Colony

The Roanoke Colony, established in the late 16th century, mysteriously vanished around 1590, leaving behind the cryptic word “Croatoan.” Founded by Sir Walter Raleigh, the colony was England’s first attempt to establish a permanent settlement in North America. The disappearance of the Roanoke settlers remains one of the greatest mysteries in American history, sparking various theories ranging from integration with local Native tribes to disaster or relocation. The lost colony of Roanoke symbolizes the challenges and uncertainties of early colonial ventures.